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Hydrogen Sulfide Attenuates Opioid Dependence by Suppression of Adenylate Cyclase/cAMP Pathway

Aims: The best-established mechanism of opioid dependence is the up-regulation of adenylate cyclase (AC)/cAMP pathway, which was reported to be negatively regulated by hydrogen sulfide (H(2)S), a novel endogenous neuromodulator. The present study was, therefore, designed to determine whether H(2)S i...

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Autors principals: Yang, Hai-Yu, Wu, Zhi-Yuan, Wood, Mark, Whiteman, Matthew, Bian, Jin-Song
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880902/
https://ncbi.nlm.nih.gov/pubmed/23682813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5119
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