BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition

PURPOSE: Recurrent “driver” mutations at specific loci in BRAF, NRAS, KIT, GNAQ, and GNA11 define clinically-relevant molecular subsets of melanoma, but >30% are “pan-negative” for these recurrent mutations. We sought to identify additional potential drivers in “pan-negative” melanoma. EXPERIMENT...

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Autori principali: Hutchinson, Katherine E., Lipson, Doron, Stephens, Philip J., Otto, Geoff, Lehmann, Brian D., Lyle, Pamela L., Vnencak-Jones, Cindy L., Ross, Jeffrey S., Pietenpol, Jennifer A., Sosman, Jeffrey A., Puzanov, Igor, Miller, Vincent A., Pao, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880773/
https://ncbi.nlm.nih.gov/pubmed/24345920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1746
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