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Protein Kinase D-mediated phosphorylation at serine 99 regulates localization of p21-activated kinase 4
p21-activated kinases (PAKs) are effectors of RhoGTPases. PAK4 contributes to regulation of cofilin at the leading edge of migrating cells through activation of Lin-11/Isl-1/Mec-3 kinase (LIMK). PAK4 activity is regulated by an autoinhibitory domain that is released upon RhoGTPase binding as well as...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3880571/ https://ncbi.nlm.nih.gov/pubmed/23841590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130281 |
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