A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice

Our goal is to develop a rapid and scalable system for functionally evaluating deregulated genes in multiple myeloma (MM). Here, we forcibly expressed human cMYC and KRAS12V in mouse T2 B cells (IgM(+)B220(+)CD38(+)IgD(+)) using retroviral transduction and transplanted these cells into lethally irra...

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Detalhes bibliográficos
Main Authors: Hu, Y, Zheng, M, Gali, R, Tian, Z, Topal Görgün, G, Munshi, N C, Mitsiades, C S, Anderson, K C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880436/
https://ncbi.nlm.nih.gov/pubmed/24185503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.53
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