Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). However, how MLKL functions to mediate necroptosis is unknown. By reconstitution of MLKL functio...

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Detalhes bibliográficos
Main Authors: Chen, Xin, Li, Wenjuan, Ren, Junming, Huang, Deli, He, Wan-ting, Song, Yunlong, Yang, Chao, Li, Wanyun, Zheng, Xinru, Chen, Pengda, Han, Jiahuai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879712/
https://ncbi.nlm.nih.gov/pubmed/24366341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.171
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