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Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis
It has been shown that SIRT7 regulates rDNA transcription and that reduced SIRT7 levels inhibit tumor growth. This anti-tumor effect could be due to reduced Pol I activity and perturbed ribosome biogenesis. In this study, using pulse labeling with RNA and amino acid analogs, we found that SIRT7 knoc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879631/ https://ncbi.nlm.nih.gov/pubmed/24113281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.031377 |
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