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Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

Among mammalian sirtuins, SIRT7 is the only enzyme residing in nucleoli where ribosomal DNA is transcribed. Recent reports established that SIRT7 associates with RNA Pol I machinery and is required for rDNA transcription. Although defined by its homology to the yeast histone deacetylase Sir2, curren...

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Autores principales: Tsai, Yuan-Chin, Greco, Todd M., Boonmee, Apaporn, Miteva, Yana, Cristea, Ileana M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277772/
https://ncbi.nlm.nih.gov/pubmed/22147730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.015156
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