Mutational and Structural Analysis of the Tandem Zinc Finger Domain of Tristetraprolin

Tristetraprolin (TTP), the best known member of a class of tandem (R/K)YKTELCX(8)CX(5)CX(3)H zinc finger proteins, can destabilize target mRNAs by first binding to AU-rich elements (AREs) in their 3′-untranslated regions (UTRs) and subsequently promoting deadenylation and ultimate destruction of tho...

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Detalhes bibliográficos
Main Authors: Lai, Wi S., Perera, Lalith, Hicks, Stephanie N., Blackshear, Perry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879578/
https://ncbi.nlm.nih.gov/pubmed/24253039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466326
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