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Mutational and Structural Analysis of the Tandem Zinc Finger Domain of Tristetraprolin

Tristetraprolin (TTP), the best known member of a class of tandem (R/K)YKTELCX(8)CX(5)CX(3)H zinc finger proteins, can destabilize target mRNAs by first binding to AU-rich elements (AREs) in their 3′-untranslated regions (UTRs) and subsequently promoting deadenylation and ultimate destruction of tho...

詳細記述

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書誌詳細
主要な著者: Lai, Wi S., Perera, Lalith, Hicks, Stephanie N., Blackshear, Perry J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
RNA
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879578/
https://ncbi.nlm.nih.gov/pubmed/24253039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466326
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