Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor

To survive and replicate within the human host, malaria parasites must invade erythrocytes. Invasion can be mediated by the P. falciparum reticulocyte-binding homologue protein 4 (PfRh4) on the merozoite surface interacting with complement receptor type 1 (CR1, CD35) on the erythrocyte membrane. The...

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Detalhes bibliográficos
Main Authors: Park, Hyon Ju, Guariento, Mara, Maciejewski, Mateusz, Hauhart, Richard, Tham, Wai-Hong, Cowman, Alan F., Schmidt, Christoph Q., Mertens, Haydyn D. T., Liszewski, M. Kathryn, Hourcade, Dennis E., Barlow, Paul N., Atkinson, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879568/
https://ncbi.nlm.nih.gov/pubmed/24214979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520346
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