Simulations of Enhancer Evolution Provide Mechanistic Insights into Gene Regulation

There is growing interest in models of regulatory sequence evolution. However, existing models specifically designed for regulatory sequences consider the independent evolution of individual transcription factor (TF)–binding sites, ignoring that the function and evolution of a binding site depends o...

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Detalhes bibliográficos
Main Authors: Duque, Thyago, Samee, Md. Abul Hassan, Kazemian, Majid, Pham, Hannah N., Brodsky, Michael H., Sinha, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879441/
https://ncbi.nlm.nih.gov/pubmed/24097306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst170
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