Subtle Changes in Motif Positioning Cause Tissue-Specific Effects on Robustness of an Enhancer's Activity

Deciphering the specific contribution of individual motifs within cis-regulatory modules (CRMs) is crucial to understanding how gene expression is regulated and how this process is affected by sequence variation. But despite vast improvements in the ability to identify where transcription factors (T...

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Bibliografske podrobnosti
Main Authors: Erceg, Jelena, Saunders, Timothy E., Girardot, Charles, Devos, Damien P., Hufnagel, Lars, Furlong, Eileen E. M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879207/
https://ncbi.nlm.nih.gov/pubmed/24391522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004060
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