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Subtle Changes in Motif Positioning Cause Tissue-Specific Effects on Robustness of an Enhancer's Activity

Deciphering the specific contribution of individual motifs within cis-regulatory modules (CRMs) is crucial to understanding how gene expression is regulated and how this process is affected by sequence variation. But despite vast improvements in the ability to identify where transcription factors (T...

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Bibliografische gegevens
Hoofdauteurs: Erceg, Jelena, Saunders, Timothy E., Girardot, Charles, Devos, Damien P., Hufnagel, Lars, Furlong, Eileen E. M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879207/
https://ncbi.nlm.nih.gov/pubmed/24391522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004060
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