Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4(pos) T cells and macrophages

BACKGROUND: Sialic acid-binding Ig-like lectin-7 (Siglec-7) expression is strongly reduced on natural killer (NK) cells from HIV-1 infected viremic patients. To investigate the mechanism(s) underlying this phenomenon, we hypothesized that Siglec-7 could contribute to the infection of CD4(pos) target...

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Main Authors: Varchetta, Stefania, Lusso, Paolo, Hudspeth, Kelly, Mikulak, Joanna, Mele, Dalila, Paolucci, Stefania, Cimbro, Raffaello, Malnati, Mauro, Riva, Agostino, Maserati, Renato, Mondelli, Mario U, Mavilio, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878752/
https://ncbi.nlm.nih.gov/pubmed/24330394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-154
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