Nitric Oxide-Mediated Regulation of Gamma Interferon-Induced Bacteriostasis: Inhibition and Degradation of Human Indoleamine 2,3-Dioxygenase

Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-γ)-inducible antimicrobial effector mechanisms in human cells. On the other hand, nitric oxide (NO) produced by the inducible isoform of NO...

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Bibliografiske detaljer
Main Authors: Hucke, Christian, MacKenzie, Colin R., Adjogble, Koku D. Z., Takikawa, Osamu, Däubener, Walter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC387869/
https://ncbi.nlm.nih.gov/pubmed/15102781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.2723-2730.2004
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