Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections

Gamma interferon (IFN-γ)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts of l-tryptophan. Both IFN-α a...

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Autori principali: Adams, O., Besken, K., Oberdörfer, C., MacKenzie, C. R., Takikawa, O., Däubener, W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC369218/
https://ncbi.nlm.nih.gov/pubmed/14963171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.5.2632-2636.2004
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