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Toxopain-1 Is Critical for Infection in a Novel Chicken Embryo Model of Congenital Toxoplasmosis

We tested the hypothesis that cathepsins and specifically toxopain-1, a cathepsin B, play a critical role in the pathogenesis of toxoplasmosis. We found that inhibiting the expression of toxopain-1-specific mRNA and protein by >60% significantly decreased the capacity of the parasites to multiply...

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Detalhes bibliográficos
Main Authors: Que, Xuchu, Wunderlich, Annette, Joiner, Keith A., Reed, Sharon L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387868/
https://ncbi.nlm.nih.gov/pubmed/15102804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.2915-2921.2004
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