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The role of disordered protein regions in the assembly of decapping complexes and RNP granules
The removal of the 5′ cap structure by the decapping enzyme DCP2 inhibits translation and generally commits the mRNA to irreversible 5′-to-3′ exonucleolytic degradation by XRN1. DCP2 catalytic activity is stimulated by DCP1, and these proteins form the conserved core of the decapping complex. Additi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877753/ https://ncbi.nlm.nih.gov/pubmed/24352420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.227843.113 |
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