The UL12.5 Gene Product of Herpes Simplex Virus Type 1 Exhibits Nuclease and Strand Exchange Activities but Does Not Localize to the Nucleus

The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a null mutant of UL12 displays a severe growth defect. Although the precise in vivo role of UL12 has not yet been determined, several in vitro activities have been id...

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Bibliographic Details
Main Authors: Reuven, Nina Bacher, Antoku, Susumu, Weller, Sandra K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC387724/
https://ncbi.nlm.nih.gov/pubmed/15078942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4599-4608.2004
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