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Dynamics of Leading-strand Lesion Skipping by the Replisome

The E. coli replisome stalls transiently when it encounters a lesion in the leading-strand template, skipping over the damage by reinitiating replication at a new primer synthesized downstream by the primase. We report here that template unwinding and lagging-strand synthesis continue downstream of...

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Bibliografski detalji
Glavni autori: Yeeles, Joseph T.P., Marians, Kenneth J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877186/
https://ncbi.nlm.nih.gov/pubmed/24268579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.020
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