Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure

Apoptosis of uninfected bystander CD4(+) T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander apoptosis are not well understood. To investigate properties of the viral envelope glycoproteins (Env...

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Detalhes bibliográficos
Main Authors: Holm, Geoffrey H., Zhang, Chengsheng, Gorry, Paul R., Peden, Keith, Schols, Dominique, De Clercq, Erik, Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387714/
https://ncbi.nlm.nih.gov/pubmed/15078935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4541-4551.2004
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