RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McLure, Kevin G., Gesner, Emily M., Tsujikawa, Laura, Kharenko, Olesya A., Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K., Wong, Norman C. W., Wagner, Gregory S., Hansen, Henrik C., Young, Peter R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877016/
https://ncbi.nlm.nih.gov/pubmed/24391744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083190
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