RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results...

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Main Authors: McLure, Kevin G., Gesner, Emily M., Tsujikawa, Laura, Kharenko, Olesya A., Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K., Wong, Norman C. W., Wagner, Gregory S., Hansen, Henrik C., Young, Peter R.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877016/
https://ncbi.nlm.nih.gov/pubmed/24391744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083190
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