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Interaction with RXR is Necessary for NPM-RAR-Induced Myeloid Differentiation Blockade
The t(5;17)(q35;q21) APL variant results in expression of a fusion protein linking the N-terminus of nucleophosmin (NPM) to the C-terminus of the retinoic acid receptor alpha (RAR). We have previously shown that NPM-RAR is capable of binding to DNA either as a homodimer or heterodimer with RXR. To d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876950/ https://ncbi.nlm.nih.gov/pubmed/24183235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.09.024 |
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