Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells

Proteasome activity is frequently enhanced in cancer to accelerate metastasis and tumorigenesis. REGγ, a proteasome activator known to promote p53/p21/p16 degradation, is often overexpressed in cancer cells. Here we show that p53/TGF-β signalling inhibits the REGγ–20S proteasome pathway by repressin...

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Hlavní autoři: Ali, Amjad, Wang, Zhuo, Fu, Junjiang, Ji, Lei, Liu, Jiang, Li, Lei, Wang, Hui, Chen, Jiwu, Caulin, Carlos, Myers, Jeffrey N., Zhang, Pei, Xiao, Jianru, Zhang, Bianhong, Li, Xiaotao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876931/
https://ncbi.nlm.nih.gov/pubmed/24157709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3667
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