α4α6β2* Nicotinic Acetylcholine Receptor Activation on Ventral Tegmental Area Dopamine Neurons Is Sufficient to Stimulate a Depolarizing Conductance and Enhance Surface AMPA Receptor Function

Tobacco addiction is a serious threat to public health in the United States and abroad, and development of new therapeutic approaches is a major priority. Nicotine activates and/or desensitizes nicotinic acetylcholine receptors (nAChRs) throughout the brain. nAChRs in ventral tegmental area (VTA) do...

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Bibliographic Details
Main Authors: Engle, Staci E., Shih, Pei-Yu, McIntosh, J. Michael, Drenan, Ryan M.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876818/
https://ncbi.nlm.nih.gov/pubmed/23788655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087346
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