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Multiple Modes of α7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents

Positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of α7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate α7 receptor function, potentially distinguishing effects requiring ion...

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Autori principali: Peng, Can, Kimbrell, Matthew R., Tian, Chengju, Pack, Thomas F., Crooks, Peter A., Fifer, E. Kim, Papke, Roger L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876815/
https://ncbi.nlm.nih.gov/pubmed/23839567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.086462
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