Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells

Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in T-cell lymphomas. Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1)...

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Detalhes bibliográficos
Main Authors: Mori, Naoki, Matsuda, Takehiro, Tadano, Masayuki, Kinjo, Takao, Yamada, Yasuaki, Tsukasaki, Kunihiro, Ikeda, Shuichi, Yamasaki, Yoshihiro, Tanaka, Yuetsu, Ohta, Takao, Iwamasa, Teruo, Tomonaga, Masao, Yamamoto, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387669/
https://ncbi.nlm.nih.gov/pubmed/15078940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4582-4590.2004
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