Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring

Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited. We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitiv...

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Main Authors: Chu, Sophie, Zhang, Hanjie, Maher, Christina, McDonald, Jacob D., Zhang, Xiang, Ho, Shuk-Mei, Yan, Beizhan, Chillrud, Steven, Perera, Frederica, Factor, Phillip, Miller, Rachel L.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876588/
https://ncbi.nlm.nih.gov/pubmed/24454363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/603581
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