Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring

Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited. We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitiv...

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Detalhes bibliográficos
Main Authors: Chu, Sophie, Zhang, Hanjie, Maher, Christina, McDonald, Jacob D., Zhang, Xiang, Ho, Shuk-Mei, Yan, Beizhan, Chillrud, Steven, Perera, Frederica, Factor, Phillip, Miller, Rachel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876588/
https://ncbi.nlm.nih.gov/pubmed/24454363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/603581
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