Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Short lipidated peptide sequences derived from various intracellular loop regions of G protein-coupled receptors (GPCRs) are named pepducins and act as allosteric modulators of a number of GPCRs. Recently, a pepducin selectively targeting the C-X-C chemokine receptor type 4 (CXCR4) was found to be a...

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Detalhes bibliográficos
Main Authors: Quoyer, Julie, Janz, Jay M., Luo, Jiansong, Ren, Yong, Armando, Sylvain, Lukashova, Viktoria, Benovic, Jeffrey L., Carlson, Kenneth E., Hunt, Stephen W., Bouvier, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876208/
https://ncbi.nlm.nih.gov/pubmed/24309376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312515110
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