Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles

Recently, we have shown that macrophage (MΦ)-induced invasion of breast cancer cells requires upregulation of Wnt 5a in MΦ leading to activation of β-Catenin-independent Wnt signaling in the tumor cells. However, it remained unclear, how malignant cells induce Wnt 5a in MΦ and how it is transferred...

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Bibliographic Details
Main Authors: Menck, Kerstin, Klemm, Florian, Gross, Julia Christina, Pukrop, Tobias, Wenzel, Dirk, Binder, Claudia
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875769/
https://ncbi.nlm.nih.gov/pubmed/24185202
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