Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

The formation of an activated cis-3-cyclohexylpropenoic acid by Plm1, the first extension module of the phoslactomycin PKS, is proposed to occur through an L-3-hydroxyacyl-intermediate as a result of ketoreduction by an A-type ketoreductase (KR). Here, we demonstrate that the KR domain of Plm1 (PlmK...

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Bibliographic Details
Main Authors: Bonnett, Shilah A., Whicher, Jonathan R., Papireddy, Kancharla, Florova, Galina, Smith, Janet L., Reynolds, Kevin A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875705/
https://ncbi.nlm.nih.gov/pubmed/23790488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.04.014
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