Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome

PURPOSE. Fibrillins are the major constituent of tissue microfibrils, which form the ocular zonule. In Marfan syndrome (MFS), FBN1 mutations lead to ectopia lentis. The goal of this work was to investigate zonule composition and formation in fibrillin-deficient and wild-type mice. METHODS. Immunoflu...

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Autores principales: Beene, Lauren C., Wang, Lauren W., Hubmacher, Dirk, Keene, Douglas R., Reinhardt, Dieter P., Annis, Douglas S., Mosher, Deane F., Mecham, Robert P., Traboulsi, Elias I., Apte, Suneel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875392/
https://ncbi.nlm.nih.gov/pubmed/24265020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13121
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