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Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction

Homocystinuria is a genetic disorder resulting in elevated levels of homocysteine in plasma and tissues. Some of the skeletal and ocular symptoms such as long-bone overgrowth, scoliosis and ectopia lentis overlap with symptoms seen in Marfan syndrome. Marfan syndrome is caused by mutations in the ex...

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Main Authors: Hubmacher, Dirk, Sabatier, Laetitia, Annis, Douglas S., Mosher, Deane F., Reinhardt, Dieter P.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112360/
https://ncbi.nlm.nih.gov/pubmed/21561146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200183z
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