The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 genes

We previously identified a Gdac1 (Gpx-deficiency-associated colitis 1) locus that influences the severity of spontaneous colitis in Gpx1- and Gpx2-double knockout (Gpx1/2-DKO) mice. Congenic Gpx1/2-DKO mice in the129S1/SvImJ (129) background but carrying the Gdac1(B6) allele have milder spontaneous...

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Hauptverfasser: Esworthy, R. Steven, Kim, Byung-Wook, Wang, Yufeng, Gao, Qiang, Doroshow, James H, Leto, Thomas L, Chu, Fong-Fong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875339/
https://ncbi.nlm.nih.gov/pubmed/24090658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.09.013
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