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Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint

Whether the presence of steroid receptors in luminal breast cancers renders them resistant to taxanes remains uncertain. Here we assess the role of progesterone receptors (PR) on taxane-induced cell death. We previously showed that estrogen receptor (ER)-positive human breast cancer cells that induc...

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Detalhes bibliográficos
Main Authors: Badtke, Melanie M., Jambal, Purevsuren, Dye, Wendy W., Spillman, Monique A., Post, Miriam D., Horwitz, Kathryn B., Jacobsen, Britta M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875321/
https://ncbi.nlm.nih.gov/pubmed/21340479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-011-1399-0
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