Nitroglycerine-Induced Nitrate Tolerance Compromises Propofol Protection of the Endothelial Cells against TNF-α: The Role of PKC-β (2) and NADPH Oxidase

Continuous treatment with organic nitrates causes nitrate tolerance and endothelial dysfunction, which is involved with protein kinase C (PKC) signal pathway and NADPH oxidase activation. We determined whether chronic administration with nitroglycerine compromises the protective effects of propofol...

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Detalhes bibliográficos
Main Authors: Lei, Shaoqing, Su, Wating, Liu, Huimin, Xu, Jinjin, Xia, Zhong-yuan, Yang, Qing-jun, Qiao, Xin, Du, Yun, Zhang, Liangqing, Xia, Zhengyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874952/
https://ncbi.nlm.nih.gov/pubmed/24396568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/678484
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