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Olfactory Bulb and Hypothalamic Acute Phase Responses to Influenza Virus: Effects of Immunization

Within hours of intranasal challenge, mouse-adapted H1N1 A/Puerto Rico/8/34 (PR8) influenza genomic RNA is found in the olfactory bulb (OB) and OB pro-inflammatory cytokines are up-regulated. Severing the olfactory tract delays the acute phase response (APR) and the APR is attenuated by immunization...

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Detalhes bibliográficos
Main Authors: Zielinski, Mark R., Souza, Gianne, Taishi, Ping, Bohnet, Stewart G., Krueger, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874867/
https://ncbi.nlm.nih.gov/pubmed/23948712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000351716
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