Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells

BACKGROUND AND PURPOSE: This study aimed to evaluate the anti-hepatitis C virus (HCV) activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, and to identify the signalling pathway involved in its antiviral action. EXPERIMENTAL APPROACH: Using HCV replicon and HCVc...

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Main Authors: Lee, Jin-Ching, Tseng, Chin-Kai, Young, Kung-Chia, Sun, Hung-Yu, Wang, Shainn-Wei, Chen, Wei-Chun, Lin, Chun-Kuang, Wu, Yu-Hsuan
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2014
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874710/
https://ncbi.nlm.nih.gov/pubmed/24117426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12440
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