Melatonin MT(1) and MT(2) receptors display different molecular pharmacologies only in the G-protein coupled state

BACKGROUND AND PURPOSE: Melatonin receptors have been extensively characterized regarding their affinity and pharmacology, mostly using 2-[(125)I]-melatonin as a radioligand. Although [(3)H]-melatonin has the advantage of corresponding to the endogenous ligand of the receptor, its binding has not be...

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Autors principals: Legros, Céline, Devavry, Séverine, Caignard, Sarah, Tessier, Clémence, Delagrange, Philippe, Ouvry, Christine, Boutin, Jean A, Nosjean, Olivier
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2014
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874706/
https://ncbi.nlm.nih.gov/pubmed/24117008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12457
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