Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19(ARF) tumor suppressor

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Here, we provide evidence that the Forkhead Box (Fox) m1b (Foxm1b or Foxm1) transcription factor is essential for the development of HCC. Conditionally deleted Foxm1b mouse hepatocytes fail to proliferate and are h...

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Detaylı Bibliyografya
Asıl Yazarlar: Kalinichenko, Vladimir V., Major, Michael L., Wang, Xinhe, Petrovic, Vladimir, Kuechle, Joseph, Yoder, Helena M., Dennewitz, Margaret B., Shin, Brian, Datta, Abhishek, Raychaudhuri, Pradip, Costa, Robert H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2004
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC387422/
https://ncbi.nlm.nih.gov/pubmed/15082532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1200704
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