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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19(ARF) tumor suppressor

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Here, we provide evidence that the Forkhead Box (Fox) m1b (Foxm1b or Foxm1) transcription factor is essential for the development of HCC. Conditionally deleted Foxm1b mouse hepatocytes fail to proliferate and are h...

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Autors principals: Kalinichenko, Vladimir V., Major, Michael L., Wang, Xinhe, Petrovic, Vladimir, Kuechle, Joseph, Yoder, Helena M., Dennewitz, Margaret B., Shin, Brian, Datta, Abhishek, Raychaudhuri, Pradip, Costa, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC387422/
https://ncbi.nlm.nih.gov/pubmed/15082532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1200704
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