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The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment

Lgr5 is a membrane protein related to G protein-coupled receptors (GPCR)s whose expression identifies stem cells in multiple tissues and is strongly correlated with cancer. Despite the recent identification of endogenous ligands for Lgr5, its mode of signaling remains enigmatic. The ability to coupl...

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Detalhes bibliográficos
Main Authors: Snyder, Joshua C., Rochelle, Lauren K., Barak, Larry S., Caron, Marc G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873998/
https://ncbi.nlm.nih.gov/pubmed/24386388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084476
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