Loss of Canonical Smad4 Signaling Promotes KRAS Driven Malignant Transformation of Human Pancreatic Duct Epithelial Cells and Metastasis

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death in North America. Activating KRAS mutations and Smad4 loss occur in approximately 90% and 55% of PDAC, respectively. While their roles in the early stages of PDAC development have been confirmed in genetically mo...

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Bibliografiske detaljer
Main Authors: Leung, Lisa, Radulovich, Nikolina, Zhu, Chang-Qi, Wang, Dennis, To, Christine, Ibrahimov, Emin, Tsao, Ming-Sound
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873993/
https://ncbi.nlm.nih.gov/pubmed/24386371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084366
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