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Conformational Stability of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Dictates Its Substrate Selectivity

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) converts inositol 1,3,4,5,6-pentakisphosphate(IP(5)) to inositol hexakisphosphate (IP(6)). IPK1 shares structural similarity with protein kinases and is suspected to employ a similar mechanism of activation. Previous studies revealed roles for the...

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Bibliographische Detailangaben
Hauptverfasser: Gosein, Varin, Miller, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873539/
https://ncbi.nlm.nih.gov/pubmed/24165122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512731
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