Design of Optimized Hypoxia-Activated Prodrugs Using Pharmacokinetic/Pharmacodynamic Modeling

Hypoxia contributes to resistance of tumors to some cytotoxic drugs and to radiotherapy, but can in principle be exploited with hypoxia-activated prodrugs (HAP). HAP in clinical development fall into two broad groups. Class I HAP (like the benzotriazine N-oxides tirapazamine and SN30000), are activa...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Foehrenbacher, Annika, Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2013
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873531/
https://ncbi.nlm.nih.gov/pubmed/24409417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00314
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky