Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks Aβ neurotoxicity. We asked if clusterin, known...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Paul Simons, J, Lovestone, Simon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873038/
https://ncbi.nlm.nih.gov/pubmed/23164821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2012.163
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