Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks Aβ neurotoxicity. We asked if clusterin, known...

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Bibliografski detalji
Glavni autori: Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Paul Simons, J, Lovestone, Simon
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873038/
https://ncbi.nlm.nih.gov/pubmed/23164821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2012.163
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