Affinity and Kinetic Modulation of Polyamide–DNA Interactions by N-Modification of the Heterocycles

Synthetic N-methyl imidazole and N-pyrrole containing polyamides (PAs) that can form “stacked” dimers can be programmed to target and bind to specific DNA sequences and control gene expression. To accomplish this goal, the development of PAs with lower molecular mass which allows for the molecules t...

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Autors principals: Ramos, Joseph P., Babu, Balaji, Chavda, Sameer, Liu, Yang, Plaunt, Adam, Ferguson, Amanda, Savagian, Mia, Lee, Megan, Tzou, Samuel, Lin, Shicai, Kiakos, Konstantinos, Wang, Shuo, Lee, Moses, Hartley, John A., Wilson, W. David
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872963/
https://ncbi.nlm.nih.gov/pubmed/23712486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22205
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