Affinity and Kinetic Modulation of Polyamide–DNA Interactions by N-Modification of the Heterocycles

Synthetic N-methyl imidazole and N-pyrrole containing polyamides (PAs) that can form “stacked” dimers can be programmed to target and bind to specific DNA sequences and control gene expression. To accomplish this goal, the development of PAs with lower molecular mass which allows for the molecules t...

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Autori principali: Ramos, Joseph P., Babu, Balaji, Chavda, Sameer, Liu, Yang, Plaunt, Adam, Ferguson, Amanda, Savagian, Mia, Lee, Megan, Tzou, Samuel, Lin, Shicai, Kiakos, Konstantinos, Wang, Shuo, Lee, Moses, Hartley, John A., Wilson, W. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872963/
https://ncbi.nlm.nih.gov/pubmed/23712486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22205
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