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Conformational Modulation of DNA by Polyamide Binding: Structural Effects of f-Im-Py-Im Based Derivatives on 5’-ACGCGT-3’

The DNA sequence 5’-ACGCGT-3’ is in the core site of the Mlu1 cell-cycle box, a transcriptional element in the promoter region of human Dbf4 gene which is highly correlated with a large number of aggressive solid cancers. The polyamide formamido-Imidazole-Pyrrole-Imidazole-Amine(+) (f-Im-Py-Im-Am(+)...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Wang, Shuo, Chai, Yun, Babu, Balaji, Satam, Vijay, Lee, Moses, Wilson, W. David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814215/
https://ncbi.nlm.nih.gov/pubmed/23784989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2273
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