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Conformational Modulation of DNA by Polyamide Binding: Structural Effects of f-Im-Py-Im Based Derivatives on 5’-ACGCGT-3’
The DNA sequence 5’-ACGCGT-3’ is in the core site of the Mlu1 cell-cycle box, a transcriptional element in the promoter region of human Dbf4 gene which is highly correlated with a large number of aggressive solid cancers. The polyamide formamido-Imidazole-Pyrrole-Imidazole-Amine(+) (f-Im-Py-Im-Am(+)...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814215/ https://ncbi.nlm.nih.gov/pubmed/23784989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2273 |
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